(For English version, see below.)
Die Abteilung Lebenswissenschaften und Gesundheitstechnologien bietet im Wintersemester 2023/24 erstmalig ihre Ringvorlesung an (4 Termine pro Semester) und lädt herzlich alle Mitglieder des PK NRW und Interessierte der Trägerhochschulen dazu ein. Die Veranstaltungen werden online angeboten. Der Link zu den einzelnen Vorträgen wird im Vorfeld durch die Koordination per E-Mail an alle Mitglieder der Abteilung sowie auf Anfrage an Interessierte gesendet.
Freitag, 26. Januar 2023, 10:00-11:30 Uhr
Medical significance of cell mechanics and advanced cell force measurement Technology
Prof. Dr. Aysegül Artmann (FH Aachen)
As the architectonical framework of all eukaryotic cells, the cytoskeleton (the microtubules, intermediate filaments, etc.) is the base for all mechanical processes on the cellular level, from proliferation over migration to wound healing and aging. Even though these filaments have already been vastly researched by quantitative methods such as gel electrophoresis, PCR, and Elisa, especially their uni - biaxial mechanical interaction and their rearrangements-responses have many open questions.
Hypertension, wound healing, and aging in-vitro models have been used at our institute, and the presentation will focus on these examples and published papers.
The mechanopathophysiological changes at the cellular level are a complicated natural process. Most of our organism systems' cells work under mechanical load, influenced significantly by the cell membrane, cell cytoskeleton, etc., and by the extracellular tissue matrix.
The cell cytoskeleton changes by induced aging changes might have remarkable impacts on the mechano-responses of a cell. We will also focus on understanding these mechano–responses from sensing (inputs) to responding (outputs).
The CellDrum-based Cell Force Measurement Technology technology was initially developed based on the ideas of Prof. Dr. rer. nat. habil Gerhard Artmann, and it will be presented during the talk. This technology allows the measurement of functional cellular force generation, considering the cellular arrangement and composition of the extracellular matrix (ECM) and the anchoring of the cells within the surrounding matrix.
Cellular mechanobiology research provides crucial progress to understand better many medical pathophysiological mechanisms like cardiovascular, gastrointestinal system, and/or skin problems. It will reveal new insights for more effective therapy approaches, including personalized medicine, in the future.
English version:
The Department for Life Sciences and Health Technologies is offering its lecture series for the first time in the winter semester of 2023/24 (4 sessions per semester) and warmly invites all members of the PK NRW and interested individuals from our Supporting Universities to attend. The events will be held online. The link to each lecture will be sent in advance via email to all department members and upon request to interested parties.
Friday, 26 January 2023, 10:00-11:30 a.m.
Medical significance of cell mechanics and advanced cell force measurement Technology
Prof. Dr. Aysegül Artmann (FH Aachen)
As the architectonical framework of all eukaryotic cells, the cytoskeleton (the microtubules, intermediate filaments, etc.) is the base for all mechanical processes on the cellular level, from proliferation over migration to wound healing and aging. Even though these filaments have already been vastly researched by quantitative methods such as gel electrophoresis, PCR, and Elisa, especially their uni - biaxial mechanical interaction and their rearrangements-responses have many open questions.
Hypertension, wound healing, and aging in-vitro models have been used at our institute, and the presentation will focus on these examples and published papers.
The mechanopathophysiological changes at the cellular level are a complicated natural process. Most of our organism systems' cells work under mechanical load, influenced significantly by the cell membrane, cell cytoskeleton, etc., and by the extracellular tissue matrix.
The cell cytoskeleton changes by induced aging changes might have remarkable impacts on the mechano-responses of a cell. We will also focus on understanding these mechano–responses from sensing (inputs) to responding (outputs).
The CellDrum-based Cell Force Measurement Technology technology was initially developed based on the ideas of Prof. Dr. rer. nat. habil Gerhard Artmann, and it will be presented during the talk. This technology allows the measurement of functional cellular force generation, considering the cellular arrangement and composition of the extracellular matrix (ECM) and the anchoring of the cells within the surrounding matrix.
Cellular mechanobiology research provides crucial progress to understand better many medical pathophysiological mechanisms like cardiovascular, gastrointestinal system, and/or skin problems. It will reveal new insights for more effective therapy approaches, including personalized medicine, in the future.
